Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis
Identifieur interne : 003857 ( Main/Exploration ); précédent : 003856; suivant : 003858Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis
Auteurs : Marina N. Torrero [États-Unis] ; C. Paul Morris [États-Unis] ; Blima K. Mitre [États-Unis] ; Marc P. Hübner [Allemagne] ; Ellen Mueller [États-Unis] ; Hajime Karasuyama [Japon] ; Edward Mitre [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2013.
Abstract
Basophils are increasingly recognized as playing important roles in the immune response towards helminths. In this study, we evaluated the role of basophils in vaccine-mediated protection against filariae, tissue-invasive parasitic nematodes responsible for diseases such as elephantiasis and river blindness. Protective immunity and immunological responses were assessed in BALB/c mice vaccinated with irradiated L3 stage larvae and depleted of basophils with weekly injections of anti-CD200R3 antibody. Depletion of basophils after administration of the vaccination regimen but before challenge infection did not alter protective immunity. In contrast, basophil depletion initiated prior to vaccination and continued after challenge infection significantly attenuated the protective effect conferred by vaccination. Vaccine-induced cellular immune responses to parasite antigen were substantially decreased in basophil-depleted mice, with significant decreases in CD4+ T-cell production of IL-4, IL-5, IL-10, and IFN-γ. Interestingly, skin mast cell numbers, which increased significantly after vaccination with irradiated L3 larvae, were unchanged after vaccination in basophil-depleted mice. These findings demonstrate that basophils help establish the immune responses responsible for irradiated L3 vaccine protection.
Url:
DOI: 10.1016/j.vaccine.2013.06.010
PubMed: 23777951
PubMed Central: 3733094
Affiliations:
- Allemagne, Japon, États-Unis
- District de Cologne, Pennsylvanie, Rhénanie-du-Nord-Westphalie, Région de Kantō
- Bonn, Tokyo
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Torrero</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD</wicri:regionArea><wicri:noRegion>MD</wicri:noRegion></affiliation></author><author><name sortKey="Morris, C Paul" sort="Morris, C Paul" uniqKey="Morris C" first="C. Paul" last="Morris">C. Paul Morris</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD</wicri:regionArea><wicri:noRegion>MD</wicri:noRegion></affiliation></author><author><name sortKey="Mitre, Blima K" sort="Mitre, Blima K" uniqKey="Mitre B" first="Blima K." last="Mitre">Blima K. Mitre</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, University of Pittsburgh Medical Center Passavant Hospital, Pitts-burgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology, University of Pittsburgh Medical Center Passavant Hospital, Pitts-burgh</wicri:cityArea></affiliation></author><author><name sortKey="Hubner, Marc P" sort="Hubner, Marc P" uniqKey="Hubner M" first="Marc P." last="Hübner">Marc P. 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In this study, we evaluated the role of basophils in vaccine-mediated protection against filariae, tissue-invasive parasitic nematodes responsible for diseases such as elephantiasis and river blindness. Protective immunity and immunological responses were assessed in BALB/c mice vaccinated with irradiated L3 stage larvae and depleted of basophils with weekly injections of anti-CD200R3 antibody. Depletion of basophils after administration of the vaccination regimen but before challenge infection did not alter protective immunity. In contrast, basophil depletion initiated prior to vaccination and continued after challenge infection significantly attenuated the protective effect conferred by vaccination. Vaccine-induced cellular immune responses to parasite antigen were substantially decreased in basophil-depleted mice, with significant decreases in CD4<sup>+</sup> T-cell production of IL-4, IL-5, IL-10, and IFN-γ. Interestingly, skin mast cell numbers, which increased significantly after vaccination with irradiated L3 larvae, were unchanged after vaccination in basophil-depleted mice. These findings demonstrate that basophils help establish the immune responses responsible for irradiated L3 vaccine protection.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Japon</li><li>États-Unis</li></country><region><li>District de Cologne</li><li>Pennsylvanie</li><li>Rhénanie-du-Nord-Westphalie</li><li>Région de Kantō</li></region><settlement><li>Bonn</li><li>Tokyo</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Torrero, Marina N" sort="Torrero, Marina N" uniqKey="Torrero M" first="Marina N." last="Torrero">Marina N. Torrero</name></noRegion><name sortKey="Mitre, Blima K" sort="Mitre, Blima K" uniqKey="Mitre B" first="Blima K." last="Mitre">Blima K. Mitre</name><name sortKey="Mitre, Edward" sort="Mitre, Edward" uniqKey="Mitre E" first="Edward" last="Mitre">Edward Mitre</name><name sortKey="Morris, C Paul" sort="Morris, C Paul" uniqKey="Morris C" first="C. Paul" last="Morris">C. Paul Morris</name><name sortKey="Mueller, Ellen" sort="Mueller, Ellen" uniqKey="Mueller E" first="Ellen" last="Mueller">Ellen Mueller</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Hubner, Marc P" sort="Hubner, Marc P" uniqKey="Hubner M" first="Marc P." last="Hübner">Marc P. Hübner</name></region></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Karasuyama, Hajime" sort="Karasuyama, Hajime" uniqKey="Karasuyama H" first="Hajime" last="Karasuyama">Hajime Karasuyama</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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